Association between helicobacter pylori eradication and weight gain

Background: Helicobacter Pylori is a common infection highly prevalent globally causing chronic gastritis, duodenal ulcer and gastric carcinoma. It is observed clinically that patients who underwent therapy for eradication of H Pylori developed weight gain. Objective of this study was to evaluate the association between weight gain and eradication of H pylori infection

Method: For this observational cross sectional study, 137 patients were studied after confirmation of diagnosis of H pylori. Base line data at the beginning of the study and comparison between pre- treatment and post treatment outcomes were assessed after 3 months of follow up

Result: After eradication therapy, a difference in body weight was evident from pre-treatment mean body weight of 61.7+/-12.3 kg to 62.5+/-11.2 Kg [P=0.011]. An increase in BMI was recorded from pretreatment BMI of 23.24 +/-2.1Kg/m[2] to 26.4+/-3.8 Kg/m[2] [P=0.028]. The assessment of symptoms was performed by applying Mann-Whitney U test of significance; score of symptoms showed a decline in intensity after eradication therapy. Mean score of dyspepsia decreased from 2.65 to 1.02 with a P value of 0.024, mean score of epigastric pain from 2.73 to 1.14 [P=0.041], mean upper abdomen fullness from 2.49 to 0.35[P=0.021]. A decrease in heart burn was noted 3.46 vs 0.92 [P=0.003] and loss of appetite was less severe; 2.89 vs 0.58 [P=0.011]

Conclusion: The eradication of H Pylori, after 3 months of treatment, is associated with mild weight gain

Realty or myth hyponatremia is common in admitted patients in medical wards lumhs Hyderabad

OBJECTIVE: To see the frequency of hyponatremia in hospitalized patients of medical wards at Liaquat university hospital Hyderabad

METHODOLOGY: In this Descriptive Cross-sectional Study we included 200 patients admitted in medical wards of Liaquat University Hospital Hyderabad from 1st July to31 august 2013, Serum sodium level of these patients was sent and results were recorded on a preformed profarma. We included all patients admitted in ward through emergency or out patients department

Inclusion Criteria: In this study patients attending emergency and OPD were included in between age of 12 years to 80 years

Exclusion Criteria: In this study we excluded all patients with acute myocardial infarction ,angina ,and traumatic emergency

RESULTS: Among 200 patients, we found 44%[88] patients having hyponatremia with 36%[72] patients with mild to moderate hyponatremia and 8% [16] patients have moderate to severe hyponatremia

Males have increased frequency of hyponatremia then females. Study concludes that frequency of hyponatremia is more frequent with increasing age

CONCLUSION: Hyponatremia is common problem seen in admitted patients in male wards

Frequency of various clinical and electrocardiac manifestation in patients with acute organophosphorous compound [OPC] poisoning

Background: worldwide, OPC are the most widely used insecticides in developing countries like Pakistan, where agriculture is the main occupation and easily available everywhere, therefore, the OPC poisoning is very common. WHO recently reports that pesticides poisoning occurs about 3 million/year with mortality > 3 lac/year and 99% belong to developing countries

Objective: to determine the frequency of various clinical and electro cardiac manifestation in OPC poisoning

Methodology: prospective observational study, conducted from Dec 2008 to April 2010 in Department of Medicine and Intensive Care Unit [ICU] at Liaquat University of Medical and Health Sciences, Jamshoro / Hyderabad

Results: out of 70 adult patients, 28[40%] were males and 42[60%] were females. The nature of OPC poisoning was suicidal in 58 [82.86%] and accidental/incidental in 12 [17.14%]. There were 43 [61.43%] farmers, 21 [30%] house-workers and 6 [8.57%] college students. There was a high ratio of insecticides [Melathion, Parathion, and Mite/rat House fly killer Carbamates] by ingestion/ inhalation route. The cardiac manifestations were Sinus Tachycardia in 20[28.6%], Non Cardiac Pulmonary Edema and Sinus Bradycardia 15[21.4%] each, Hypertension in 13[18.6%] and Hypotension in 07[10%]. Common ECG changes noted in our study were prolonged QTc - interval among 28[40%], prolonged P-R interval in 11[15.7%], atrial fibrillation, ventricular Tachycardia and extra systole were found as; 06 [8.6%], 05 [7.1%] and 05 [7.1%] respectively. Common neurological findings were flaccid paralysis in 28[40%] patients with respiratory muscle involvement in 10 cases, delirium in 11[17.5%], impairment of consciousness in 8[11.4%], and extrapyramidal features, fasciculation's, convulsions, and cranial nerve involvement were in 6 [8.6%], 5[7.1. %], 7[10%] and 5[7.1%] respectively

Conclusion: in routine hospital practice, the suicidal cases are very common due to acute OPC poisoning. Many cases are hospitalized with critical condition with predominant involvement of cardiac and neurological features. Early diagnosis with appropriate treatment with specific antidotes and ICU management can minimize the fatal consequences of OPC poisoning. It is further recommended that more studies are required to provide awareness regarding this important public health problem